background:
PRKAB2 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status and plays a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase (ACC). It also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase (HMGCR) and hormone-sensitive lipase. PRKAB2 may be a positive regulator of AMPK activity.
Function:
AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adapter molecule for the catalytic alpha-subunit.
Post-translational modifications:
Phosphorylated when associated with the catalytic subunit.
Similarity:
Belongs to the 5'-AMP-activated protein kinase beta subunit family.
Database links:
Entrez Gene: 5565 Human
Entrez Gene: 108097 Mouse
Entrez Gene: 64562 Rat
Omim: 602741 Human
SwissProt: O43741 Human
SwissProt: Q6PAM0 Mouse
SwissProt: Q9QZH4 Rat
Unigene: 50732 Human
Unigene: 31175 Mouse
Unigene: 207202 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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