Rabbit Anti-CACH6/Cav2.3/FITC Conjugated antibody

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BII; Brain calcium channel II; CAC 1E; CAC1E; CACH 6; CACH6; CACNA1E; Cacnl1 a6; CACNL1A6; Calcium channel, L type, alpha 1 polypeptide, isoform 6; calcium channel, R type; Cav 2.3; Cchra 1; Cchra1; Voltage dependent R type calcium channel subunit alpha 1

Cat:

SL3933R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Guinea Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human Cav23

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

262kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Calcium channels mediate the influx of calcium ions into the cell following membrane polarisation. R-type calcium channels such as Cav2.3 belong to the "high voltage-activated" group and are blocked by nickel. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Each of these proteins exists as multiple isoforms, either encoded by different genes or arising from alternative splicing of transcripts. Cav2.3 is an alpha-1 subunit and has 24 transmembrane segments, which form the pore through which ions pass into the cell. Calcium channels containing the Cav2.3 subunit may be involved in the modulation of firing patterns of neurons, which is important for information processing.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in neuronal tissues and in kidney.

Similarity:
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily.
Contains 1 EF-hand domain.

Database links:

Entrez Gene: 12290 Mouse

SwissProt: Q61290 Mouse

SwissProt: Q07652 Rat

Unigene: 267517 Mouse

Unigene: 10742 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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