background:
The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors. Eight human AC isoforms (AC1 through AC4), encoded by separate genes, have been identified up to now. Most of the adenylate cyclase genes are comprised of 11-26 exons and distributed over a q6-430 kb. The majority of the adenylate cyclases previously described are expressed discretely in defined peripheral tissues, the type 4 adenylate cyclase (AC4) is apparently expressed in a variety of peripheral tissues and in the central nervous system, mainly in olfactory system. AC5 proteins are localized on photoreceptor cells and are also designated as GC1 and GC2. The AC5 protein resembles the other adenylyl cyclases in its predicted and proposed structure. AC5 resembles the type 6 (AC6) adenylyl cyclase in its amino acid sequence but becomes divergent at N and SLCterminal ends. The AC5 and AC6 proteins are co-localized in most of the visual organs (photoreceptor cells) and are associated with other protein complexes. Both AC5 and AC6 enzymes play an important role in synaptic plasticity by coordinating overlapping synaptic inputs from Gs and Gi coupled receptor stimulation.
Function:
Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity).
Subunit:
Part of a complex containing AKAP5, ADCY5, PDE4C and PKD2 (By similarity). Interacts with RAF1.
Subcellular Location:
Membrane; Multi-pass membrane protein. Cell projection, cilium (By similarity).
Post-translational modifications:
Phosphorylated by RAF1.
Similarity:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 2 guanylate cyclase domains.
Database links:
UniProtKB/Swiss-Prot: O43306.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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