background:
The cAMP synthesizing enzymes are found in two forms: cytosolic (soluble) and membrane-bound (particulate). Stimulation of adenylate cyclases produce cAMP form ATP in response to the activation of GPCRs by various hormones, neurotransmitters and other regulatory molecules. cAMP, in subsequent steps down the signal transduction pathway, can stimulate cAMP-dependent protein kinase A (cPKA), and several other target molecules. Activation of cPKA can phosphorylate a broad range of substrates that regulate various metabolic pathways, gene expression, and affect memory functions etc. The stimulation of adenylate cyclases starts with interactions with GPCRs mediated signals initiated by Gs and Gi heterotrimeric G-proteins.
Function:
Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.
Similarity:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 2 guanylate cyclase domains.
Database links:
Entrez Gene: 109 Human
Entrez Gene: 104111 Mouse
Entrez Gene: 64508 Rat
Omim: 600291 Human
SwissProt: O60266 Human
SwissProt: Q8VHH7 Mouse
SwissProt: P21932 Rat
Unigene: 727540 Human
Unigene: 70546 Mouse
Unigene: 87800 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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