Rabbit Anti-HSD11B1/FITC Conjugated antibody

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11 beta HSD 1; 11 beta HSD1; 11 beta hydroxysteroid dehydrogenase 1; 11 DH; 11DH; Corticosteroid 11 beta dehydrogenase isozyme 1; HDL; HSD 11; HSD11; HSD11B; HSD11L; Hydroxysteroid (11 beta) dehydrogenase 1; Hydroxysteroid (11 beta) dehydrogenase; MGC1353

Cat:

SL3904R-FITC

Species Reactivity：

Human,Mouse,Rat,Horse,(predicted: Dog,Pig,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human HSD11B1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

32kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
HSD11B1 is a microsomal enzyme that catalyses the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyse the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.

Subunit:
Homodimer.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Tissue Specificity:
Widely expressed. Highest expression in liver.

Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Database links:

Entrez Gene: 3290 Human

Entrez Gene: 15483 Mouse

Entrez Gene: 25116 Rat

Omim: 600713 Human

SwissProt: Q6R0J2 Hamster

SwissProt: P28845 Human

SwissProt: P50172 Mouse

SwissProt: Q7M3I4 Rabbit

SwissProt: P16232 Rat

Unigene: 195040 Human

Unigene: 28328 Mouse

Unigene: 185798 Rat

Unigene: 888 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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