background:
GTP-binding protein 10 (GTPBP10) belongs to the GTP1/OBG family. Small G proteins, such as GTPBP10, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction; GTPBA_HUMAN; GTP-binding protein 10; Protein obg homolog 2; ObgH2.
Function:
May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nuceleolar architecture is observed.
Subcellular Location:
Nucleus, nucleolus. Chromosome. Note=Found in the dense fibrillar compartment region of the nucleolus. At the onset of mitosis moves to the chromosome surface and remains there until anaphase. Gradually re-assembles into the nucleolus at late anaphase to telophase.
Similarity:
Belongs to the GTP1/OBG family.
Database links:
Entrez Gene: 85865 Human
Entrez Gene: 207704 Mouse
Omim: 610920 Human
SwissProt: A4D1E9 Human
SwissProt: Q8K013 Mouse
Unigene: 593547 Human
Unigene: 709271 Human
Unigene: 323984 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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