background:
NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections.
Function:
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Subcellular Location:
Membrane.
Post-translational modifications:
Glycosylated.
DISEASE:
Defects in CYBB are a cause of chronic granulomatous disease X-linked (XCGD) [MIM:301280]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
Similarity:
Contains 1 FAD-binding FR-type domain.
Contains 1 ferric oxidoreductase domain.
Database links:
Entrez Gene: 281112 Cow
Entrez Gene: 1536 Human
Entrez Gene: 13058 Mouse
Entrez Gene: 100001761 Rabbit
Entrez Gene: 66021 Rat
Omim: 300481 Human
SwissProt: O46522 Cow
SwissProt: P04839 Human
SwissProt: Q61093 Mouse
Unigene: 292356 Human
Unigene: 200362 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NOX2也是一个很重要的产生氧自由基的酶。主要存在于甲状腺,前列腺，唾液腺和直肠粘膜中。
|
|
