Rabbit Anti-ATG4A/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-ATG4A/FITC Conjugated antibody

ATG4A is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, wi

Cat:

SL3873R-FITC

Species Reactivity：

Human,Mouse,Rat,(predicted: Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human ATG4A

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

45kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
ATG4A is a cysteine protease required for autophagy, which cleaves the SLCterminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed SLCterminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Function:
Cysteine protease required for autophagy, which cleaves the SLCterminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed SLCterminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.

Subcellular Location:
Cytoplasm (Probable).

Tissue Specificity:
Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.

Similarity:
Belongs to the peptidase C54 family.

Database links:

Entrez Gene: 115201 Human

Entrez Gene: 666468 Mouse

Omim: 300663 Human

SwissProt: Q8WYN0 Human

SwissProt: Q8C9S8 Mouse

Unigene: 8763 Human

Unigene: 102230 Mouse

Unigene: 39364 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall