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Rabbit Anti-CHRDL2/FITC Conjugated antibody
background:
CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. A
member of the chordin family of proteins, it contains a signal peptide and
three CR (cysteine-rich repeat) domains. When expressed as a recombinant
protein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors.
Function:
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
Subunit:
Interacts with GDF5 (By similarity). May interact with BMP2, BMP4, BMP5, BMP6, BMP7 and INHBA.
Subcellular Location:
Isoform 1: Secreted (Potential).
Isoform 2: Secreted (Potential).
Isoform 3: Cytoplasm (Potential).
Isoform 4: Cytoplasm (Potential).
Isoform 5: Cytoplasm (Potential).
Tissue Specificity:
Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma.
Post-translational modifications:
Phosphorylation sites are present in the extracellular medium. Isoform 2 is phosphorylated on Ser-402.
Similarity:
Contains 3 VWFC domains.
Database links:
Entrez Gene: 25884 Human
Omim: 613127 Human
SwissProt: Q6WN34 Human
Unigene: 432379 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CHRDL2原来主要用于乳腺癌的研究，近年来研究发现在肿瘤中也有发现，目前在肺癌，结肠肿瘤的研究中应用较多。
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