background:
Amphiregulin expression is induced by phorbol ester, estrogen, androgen, and other EGFR ligands. In vitro, amphiregulin functions as an autocrine growth stimulator to drive proliferation of colon carcinoma cells, normal and oncogene-transformed mammary epithelial cells, cervical carcinoma cells, prostate cancer cells, and keratinocytes. Amphiregulin is important in the development of human placenta and murine mammary gland. It is reportedly overexpressed in human cancers of breast, colon, stomach and pancreas.
Function:
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Subunit:
The immature precursor interacts with CNIH.
Subcellular Location:
Membrane; Single-pass membrane protein.
Similarity:
Belongs to the amphiregulin family.
Contains 1 EGF-like domain.
Database links:
Entrez Gene: 374 Human
Entrez Gene: 727738 Human
Entrez Gene: 11839 Mouse
Omim: 104128 Human
SwissProt: P15514 Human
SwissProt: P31955 Mouse
Unigene: 270833 Human
Unigene: 645475 Human
Unigene: 8039 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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