background:
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
Function:
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
Subunit:
Homotrimer.
Subcellular Location:
Membrane; Single-pass type II membrane protein (Probable). Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted.
Tissue Specificity:
Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.
Similarity:
Belongs to the tumor necrosis factor family.
Database links:
Entrez Gene: 9966 Human
Entrez Gene: 326623 Mouse
Entrez Gene: 252878 Rat
Omim: 604052 Human
SwissProt: O95150 Human
SwissProt: Q5UBV8 Mouse
SwissProt: Q8K3Y7 Rat
Unigene: 241382 Human
Unigene: 208152 Mouse
Unigene: 84873 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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