Rabbit Anti-GDF15/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-GDF15/FITC Conjugated antibody

GDF 15; GDF-15 Growth differentiation factor 15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC 1; MIC-1; MIC1; NAG 1; NAG1; NRG 1; NRG1; NSAID (nonsteroidal anti inflammatory drug) activated protein 1; NSAID; NSAID regulated prot

Cat:

SL3818R-FITC

Species Reactivity：

Human,Mouse,(predicted: Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human GDF-15

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

12.5/34kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues. GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.

Subcellular Location:
Secreted.

Tissue Specificity:
Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney.

Similarity:
Belongs to the TGF-beta family.

Database links:

Entrez Gene: 9518 Human

Entrez Gene: 23886 Mouse

Entrez Gene: 29455 Rat

Omim: 605312 Human

SwissProt: Q99988 Human

SwissProt: Q9Z0J7 Mouse

SwissProt: Q9Z0J6 Rat

Unigene: 616962 Human

Unigene: 31325 Mouse

Unigene: 44228 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生长分化因子15（GDF15）是骨形态发生蛋白（BMP）和转化生长因子-β超家族成员。GDF-15又叫巨噬细胞抑制因子（macrophage inhibiting cytokine，MIC）-1、胎盘转化生长因子（placental transformation growth factor，PTGF）-β、前列腺衍生因子（prostate derived factor，PDF）和胎盘骨形态发生蛋白（placental bone morphogeneticprotein，PLAB）。
有学者认为：GDF-15在肿瘤发展的不同阶段发挥着不同的生物学作用；随着肿瘤的发生发展，GDF-15可能表达不同形式的蛋白，在肿瘤发生的早期阶段可能发挥抑瘤作用，而在肿瘤发展的后期阶段发挥促瘤作用。

Product Feedback Wall