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Rabbit Anti-phospho-Crkl (Tyr251)/FITC Conjugated antibody
background:
Crkl is a 34kDa adaptor protein which has been shown to activate the RAS and JUN kinase signalling pathways and transforms fibroblasts in a RAS dependant manner. Crkl is a substitute of BCR ABL tyrosine kinase. In addition, Crkl has oncogenic potential.
Function:
May mediate the transduction of intracellular signals.
Subunit:
Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4.
Similarity:
Belongs to the CRK family.
Contains 1 SH2 domain.
Contains 2 SH3 domains.
Database links:
Entrez Gene: 1399 Human
Entrez Gene: 12929 Mouse
Omim: 602007 Human
SwissProt: P46109 Human
SwissProt: P47941 Mouse
Unigene: 5613 Human
Unigene: 21048 Mouse
Unigene: 451241 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
接头蛋白CrkL是Crk家族成员之一,CRKL为具有SH2及SH3结构的连接蛋白,CrkL参与多种信号转导途径调节细胞运动、增殖及分化,在各种组织中广泛表达,在多种信号途径中起重要作用。
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