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Rabbit Anti-phospho-Claudin 6 (Tyr219)/FITC Conjugated antibody
background:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]
Function:
Plays a major role in tight junction-specific obliteration of the intercellular space.
Subunit:
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
Subcellular Location:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the claudin family.
Database links:
Entrez Gene: 9074 Human
Entrez Gene: 54419 Mouse
SwissProt: P56747 Human
SwissProt: Q9Z262 Mouse
Unigene: 533779 Human
Unigene: 485133 Mouse
Unigene: 86421 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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