Rabbit Anti-Claudin 6/FITC Conjugated antibody

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Claudin6; CLDN 6; CLDN6; Skullin 2; CLD6_HUMAN; Claudin-6; Claudin 6; OTTHUMP00000159248; Skullin-2; Skullin; UNQ757/PRO1488.

Cat:

SL3754R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Horse,Rabbit,Guinea Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human Claudin 6

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

23kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]

Function:
Plays a major role in tight junction-specific obliteration of the intercellular space.

Subunit:
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.

Subcellular Location:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Similarity:
Belongs to the claudin family.

Database links:

Entrez Gene: 9074 Human

Entrez Gene: 54419 Mouse

SwissProt: P56747 Human

SwissProt: Q9Z262 Mouse

Unigene: 533779 Human

Unigene: 485133 Mouse

Unigene: 86421 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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