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Home > Product > Antibody > Rabbit Anti-phospho-STMN2 (Ser50)/FITC Conjugated antibody
Neuronal growth associated protein; SCG 10; SCG10; SCG10 protein; SCGN 10; SCGN10; SGC 10; SGC10; Stathmin 2; Stathmin like 2; STMN 2; STMN-2; Superior cervical ganglia neural specific 10; Superior cervical ganglion 10 protein; Superiorcervical ganglia ne
Cat:
SL2299R-FITC
Species Reactivity：
Rat,(predicted: Human,Mouse,Chicken,Dog,Horse,Rabbit,)
Immunogen：
KLH conjugated Synthesised phosphopeptide derived from human STMN2 around the phosphorylation site of Ser50
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
20kDa
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Product PDFs
Datasheet:


background:
This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010].

Function:
Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.

Subunit:
Interacts with MAPK8. Interacts with ITM2C.

Subcellular Location:
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cell projection, axon. Golgi apparatus. Endosome. Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms.

Tissue Specificity:
Neuron specific.

Post-translational modifications:
Sumoylated.
Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex.
N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.

Similarity:
Belongs to the stathmin family.

Database links:

Entrez Gene: 11075 Human

Entrez Gene: 20257 Mouse

Entrez Gene: 84510 Rat

Omim: 600621 Human

SwissProt: Q93045 Human

SwissProt: P55821 Mouse

SwissProt: P21818 Rat

Unigene: 521651 Human

Unigene: 29580 Mouse

Unigene: 34335 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

STMN2神经生长相关蛋白又称：颈上神经节神经特异性因子10，该蛋白可调节神经细胞的分化、神经细胞轴突的增殖及细胞骨架的构成。
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