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Rabbit Anti-PBR/FITC Conjugated antibody
background:
PBR (Peripheral type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid producing tissues and is found in association with a 34 kDa voltage dependent anion channel protein (VDAC). PBR interacts with some benzodiazepines and has different affinities than its endogenous counterpart. PBR appears to be a key factor in the transport of cholesterol from the outer to the inner mitochondrial membrane to permit the initiation of steroid hormone synthesis. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis. It is speculated that patients with congenital lipoid adrenal hyperplasia, who cannot make any steroids, might have a genetic lesion in BZRP. A short form, PBRS is also expressed in the same tissues, but at a level about ten times that of PBR.
Function:
Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells.
Subcellular Location:
Mitochondrion membrane.
Tissue Specificity:
Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.
Similarity:
Belongs to the TspO/BZRP family.
Database links:
Entrez Gene: 706 Human
Entrez Gene: 12257 Mouse
Omim: 109610 Human
SwissProt: B1AH88 Human
SwissProt: P30536 Human
SwissProt: P50637 Mouse
Unigene: 202 Human
Unigene: 1508 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
地西泮结合抑制因子;
DBI能拮抗安定物质:diazepam与脑突触膜相结合 ,故称之为安定结合抑制蛋白(DBI),地西泮结合抑制因子(diazepam binding inhibitor,DBI)具有抑制由葡萄糖诱导的胰岛素分泌、促进胆固醇跨线粒体膜转运和调节脂肪酸合成与代谢等多种生理功能。
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