background:
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. May be essential for the formation of spine apparatuses in spines of telencephalic neurons, involved in synaptic plasticity. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes.
Subunit:
Interacts with BAIAP1. Interacts with actin (By similarity). Interacts (via PPxY motifs) with WWC1 (via WW domains).
Subcellular Location:
Cytoplasm, cytoskeleton (By similarity). Cell junction, tight junction (By similarity). Perikaryon (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Asssociated with dendritic spines of a subset of synapses (By similarity).
Tissue Specificity:
Expressed in brain, namely in the olfactory bulb, cerebral cortex, striatum, and hippocampus, but not in the cerebellum. Also expressed in the podocytes of kidney glomeruli. In the hippocampus, mainly expressed in the principal cell layer of the dentate gyrus and Ammon's horn.
Similarity:
Belongs to the synaptopodin family.
Database links:
Entrez Gene: 11346 Human
Entrez Gene: 104027 Mouse
Entrez Gene: 60324 Rat
Omim: 608155 Human
SwissProt: Q8N3V7 Human
SwissProt: Q8CC35 Mouse
SwissProt: Q9Z327 Rat
Unigene: 435228 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
synaptopodin是一种与肌动蛋白微丝偶联的蛋白,其富含脯氨酸,为线状蛋白质,在动物体内表达于肾小球的足细胞和后脑的突触内,synaptopodin被认为是足细胞特异的分化成熟标志物。
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