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Rabbit Anti-GRIM19/FITC Conjugated antibody
background:
A novel gene, Genes associated with Retinoid IFN induced Mortality (GRIM) GRIM19 gene was identified. Antisense expression of GRIM19 confers a strong resistance against IFN/RA induced death by reducing the intracellular levels of GRIM19 protein. Overexpression of GRIM19 enhances cell death in response to IFN/RA. GRIM19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM19 is a novel cell death regulatory molecule.
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
Subunit:
Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with HHSLV8 IRF1, in the nucleus, with HPSLV16 E6 and SV40 LT. Interacts with OLFM4.
Subcellular Location:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus. Note=May be translocated into the nucleus upon IFN/RA treatment.
Tissue Specificity:
Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.
DISEASE:
Defects in NDUFA13 may be a cause of susceptibility to Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]. Hurthle cell thyroid carcinoma accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms.
Similarity:
Belongs to the complex I NDUFA13 subunit family.
Database links:
Entrez Gene: 338084 Cow
Entrez Gene: 51079 Human
Entrez Gene: 67184 Mouse
Entrez Gene: 314759 Rat
Omim: 609435 Human
SwissProt: Q95KV7 Cow
SwissProt: Q9P0J0 Human
SwissProt: Q9ERS2 Mouse
Unigene: 534453 Human
Unigene: 21162 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GRIM19是GRIMs凋亡相关基因新家族成员之一,是一种由IFN-β联合RA（干扰素/维甲酸）诱导表达的16kDa蛋白,分布在细胞核和胞浆中，GRIM-19是纯化的线粒体呼吸链复合体I的组成成分,这种复合物为ATP合成所必需的,当线粒体复合物I电子转移产生活性,GRIM-19突变体突破线粒体跨膜电位,可增强细胞对凋亡刺激的敏感性，它的过高表达可以抑制肿瘤细胞的增殖，促进细胞的凋亡。
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