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Home > Product > Antibody > Rabbit Anti-Phospho-Stat4 (Tyr693)/FITC Conjugated antibody
STAT4 (Phospho-Tyr693); STAT4 (Phospho Y693); p-STAT4 (Tyr693); signal transducers and activators of transduction 4; CIS4; HSPC060; SOCS4; SOCS6; SSI4; STAI4; STAT 4; STAT4; STATI4; Suppressor of cytokine signaling 6; STAT4_HUMAN.
Cat:
SL3430R-FITC
Species Reactivity：
(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,)
Immunogen：
KLH conjugated Synthesised phosphopeptide derived from human Stat4 around the phosphorylation site of Tyr693
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
82kDa
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Unit:
Price: $
Product PDFs
Datasheet:


background:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011].

Function:
Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.

Subunit:
Forms a homodimer or a heterodimer with a related family member. Interacts with ARL2BP. The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain.

Subcellular Location:
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Post-translational modifications:
Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity.

DISEASE:
Genetic variations in STAT4 are associated with susceptibility to systemic lupus erythematosus type 11 (SLEB11) [MIM:612253]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Genetic variations in STAT4 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:36300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

Similarity:
Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.

Database links:

Entrez Gene: 6775 Human

Entrez Gene: 20849 Mouse

Entrez Gene: 367264 Rat

Omim: 600558 Human

SwissProt: Q14765 Human

SwissProt: P42228 Mouse

SwissProt: Q66HB2 Rat

Unigene: 735572 Human

Unigene: 80642 Human

Unigene: 1550 Mouse

Unigene: 137580 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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