background:
NR1D1, a NR1 Thyroid Hormone-Like Receptor, is encoded by the same genomic locus as, but transcribed from the opposite strand of, Thyroid Hormone Receptor Alpha (TR Alpha). NR1D1 is a target of Nuclear Receptor ROR Alpha and a transcription regulator that has been shown to affect myocyte differentiation, adipogenesis, and lipoprotein metabolism. Mice lacking NR1D1 show abnormal postnatal cerebellar development. NR1D1 expression has been documented in human skeletal muscle and a variety of mouse and rat tissues. ESTs have been isolated from human tissue libraries, including cancerous adrenal, blood, brain, breast, colon, duodenum, fetus, head/neck, kidney, lung, skeletal muscle, skin, synovium, uterus, normal brain, breast, colon, eye, heart, pancreas, pituitary, prostate, skeletal muscle, skin, testis and thyroid.
Function:
Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription. Possible receptor for triiodothyronine.
Subunit:
Interacts with C1D and NR2E3. Interacts with SP1.
Subcellular Location:
Nucleus (Potential).
Tissue Specificity:
Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines.
Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Database links:
Entrez Gene: 768225 Cow
Entrez Gene: 9572 Human
Entrez Gene: 217166 Mouse
Entrez Gene: 252917 Rat
Omim: 60488 Human
SwissProt: Q08E02 Cow
SwissProt: P20393 Human
SwissProt: Q3UV55 Mouse
SwissProt: Q63503 Rat
Unigene: 592130 Human
Unigene: 724 Human
Unigene: 390397 Mouse
Unigene: 29848 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
1.细胞核受体Rev-Erbα是生物钟系统的重要组成部分,不仅是生物钟基因而且是生物钟调节基因,在维持生物节律准确性中发挥着重要作用；
2.Rev-Erbα调节糖代谢、脂质代谢、脂肪形成、纤溶蛋白降解、血管炎症并与其他能量平衡相关核受体相互作用。
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