background:
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Function:
Synthesis and degradation of fructose 2,6-bisphosphate.
Tissue Specificity:
Ubiquitous.
Similarity:
In the SLCterminal section; belongs to the phosphoglycerate mutase family.
Database links:
Entrez Gene: 5209 Human
Entrez Gene: 170768 Mouse
Entrez Gene: 24128 Rat
Omim: 605319 Human
SwissProt: Q16875 Human
SwissProt: P25114 Rat
Unigene: 444304 Human
Unigene: 44844 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IPFK2是糖酵解的一种重要酶,广泛存在于各种生物细胞中。由于该酶对调控糖酵解通路的重要作用.
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