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Rabbit Anti-Phospho-MEK6 (Ser202)/FITC Conjugated antibody
background:
Mitogen activated protein kinase kinase 6 (MEK6 or MKK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MEK6, closely related to MEK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38, thus activating it, in response to inflammatory cytokines and environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this protein is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
Function:
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively.
Subunit:
Interacts with Yersinia yopJ.
Tissue Specificity:
Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas.
Post-translational modifications:
Weakly autophosphorylated. Phosphorylated by TAOK2.
Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
Similarity:
Belongs to the enoyl-CoA hydratase/isomerase family.
Database links:
Entrez Gene: 5608 Human
Entrez Gene: 26399 Mouse
Entrez Gene: 114495 Rat
Omim: 601254 Human
SwissProt: P52564 Human
SwissProt: P70236 Mouse
Unigene: 463978 Human
Unigene: 14487 Mouse
Unigene: 17256 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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