Rabbit Anti-Phospho-HSL (Ser865)/FITC Conjugated antibody

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Hormone sensitive lipase; Hormone sensitive lipase testicular isoform; HSL; LHS; Lipase hormone sensitive; LIPE.

Cat:

SL3224R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Horse,)

Immunogen：

KLH conjugated Synthesised phosphopeptide derived from human HSL around the phosphorylation site of Ser865

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

117kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
HSL/LIPE is found in adipose tissue and heart, where it primarily hydrolyzes stored triglycerides to free fatty acids. It is also found in steroidogenic tissues, where it principally converts cholesteryl esters to free cholesterol for steroid hormone production. There are two named isoforms.

Function:
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.

Subcellular Location:
Cell membrane. Membrane, caveola. Cytoplasm,bcytosol. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.

Post-translational modifications:
Phosphorylation by AMPK may block translocation to lipid droplets.

Similarity:
Belongs to the 'GDXG' lipolytic enzyme family.

Database links:

Entrez Gene: 3991 Human

Entrez Gene: 16890 Mouse

Entrez Gene: 25330 Rat

Omim: 151750 Human

SwissProt: Q05469 Human

SwissProt: Q6NSL7 Human

SwissProt: P54310 Mouse

SwissProt: P15304 Rat

Unigene: 656196 Human

Unigene: 158548 Mouse

Unigene: 333679 Mouse

Unigene: 10566 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HSL又称：敏感性甘油三酯脂肪酶，在脂肪动员中，脂肪细胞内激素敏感性甘油三酯脂肪酶（HSL）起决定性作用，它是脂肪分解的限速酶，称为激素敏感性脂肪酶。肾上腺素、去甲肾上腺素、胰高血糖素等激活HSL促进脂肪动员；胰岛素，前列腺素E及烟酸等抑制HSL，抑制脂肪的动员。分子量：116KDa。

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