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Rabbit Anti-Phospho-HSL (Ser863)/FITC Conjugated antibody
background:
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
Function:
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Subunit:
Interacts with PTRF in the adipocyte cytoplasm.
Subcellular Location:
Cell membrane. Membrane, caveola. Cytoplasm, cytosol.
Post-translational modifications:
Phosphorylation by AMPK may block translocation to lipid droplets.
Similarity:
Belongs to the 'GDXG' lipolytic enzyme family.
Database links:
Entrez Gene: 3991 Human
Entrez Gene: 16890 Mouse
Entrez Gene: 25330 Rat
Omim: 151750 Human
SwissProt: Q05469 Human
SwissProt: Q6NSL7 Human
SwissProt: P54310 Mouse
SwissProt: P15304 Rat
Unigene: 656196 Human
Unigene: 158548 Mouse
Unigene: 333679 Mouse
Unigene: 10566 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
HSL又称:敏感性甘油三酯脂肪酶,在脂肪动员中,脂肪细胞内激素敏感性甘油三酯脂肪酶(HSL)起决定性作用,它是脂肪分解的限速酶,称为激素敏感性脂肪酶。肾上腺素、去甲肾上腺素、胰高血糖素等激活HSL促进脂肪动员;胰岛素,前列腺素E及烟酸等抑制HSL,抑制脂肪的动员。分子量:116KDa。
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