background:
The enzymes responsible for the reversible acetylation/ deacetylation process of histones are histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. HATs act as transcriptional coactivators and HDACs are part of transcriptional corepressor complexes. Mammalian HDACs can be divided into three classes according to sequence homology. Class I consists of the yeast Rpd3 like proteins HDAC1, HDAC2, HDAC3, and HDAC8. Class II consists of the yeast Hda1 like proteins HDAC10, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10. Class III comprises the yeast Sir2 like proteins. Whereas class I HDACs are ubiquitously expressed, most class II HDACs are tissue specific. HDAC10 is similar to HDAC6, both containing a unique putative second catalytic domain not found in other HDACs. However, this domain is not functional in HDAC10. The deacetylase activity of class II HDACs is regulated by subcellular localization. HDAC10 was localized to both the nucleus and cytoplasm. HDAC10 can deacetylate histones, repress transcription, and interact with HDAC3.
Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Subunit:
Interacts with HDAC2, HDAC3 and NCOR2.
Subcellular Location:
Cytoplasm. Nucleus. Note=Excluded from the nucleoli.
Tissue Specificity:
Ubiquitous. High expression in liver, spleen, pancreas and kidney.
Similarity:
Belongs to the histone deacetylase family. HD type 2 subfamily.
Database links:
Entrez Gene: 83933 Human
Entrez Gene: 170787 Mouse
Entrez Gene: 362981 Rat
Omim: 608544 Human
SwissProt: Q969S8 Human
SwissProt: Q6P3E7 Mouse
SwissProt: Q569C4 Rat
Unigene: 26593 Human
Unigene: 203954 Mouse
Unigene: 107028 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
