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Rabbit Anti-CACNB2/FITC Conjugated antibody
background:
This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]
Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Subunit:
The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with RRAD. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane.
Subcellular Location:
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Similarity:
Belongs to the calcium channel beta subunit family.
Contains 1 SH3 domain.
Database links:
Entrez Gene: 783 Human
Entrez Gene: 12296 Mouse
Entrez Gene: 116600 Rat
Omim: 600003 Human
SwissProt: Q08289 Human
SwissProt: Q8CC27 Mouse
SwissProt: Q8VGC3 Rat
Unigene: 59093 Human
Unigene: 313930 Mouse
Unigene: 10739 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
电压依赖性钙通道(VDCC)是生物体内一大类钙通道蛋白,随着膜电位的改变而出现通道的开放、关闭和失活,调节细胞内Ca2+浓度,最终产生生物学效应.其亚型结构各异,VDCC β亚基具有调节其通道活性的作用,VDCC存在的普遍性决定了其作用的广泛性.在胰腺、心、脑、肾上腺、视网膜及神经等组织器官均有不同程度的分布.
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