Home
>
Product
>
Antibody
>
Rabbit Anti-TNFAIP3/FITC Conjugated antibody
background:
A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor κ B (NFκB) gene expression. By inhibiting NFκB activation, A20 plays a critical role in terminating NFκB responses to various stimuli. Although the SLCterminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFκB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) γ protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases
Function:
TNFAIP3 interacts with NAF1 and inhibits TNF induced NF kappa B dependent gene expression by interfering with a RIP or TRAF2 mediated transactivation signal. It inhibits programmed cell death, has a role in the function of the lymphoid system, and may contribute to the in vivo effects of TNF.
Subcellular Location:
Cytoplasm. Nucleus.
Similarity:
Belongs to the peptidase C64 family.
Contains 7 A20-type zinc fingers.
Contains 1 OTU domain.
Database links:
Entrez Gene: 7128 Human
Entrez Gene: 21929 Mouse
Omim: 191163 Human
SwissProt: P2316 Human
SwissProt: Q60769 Mouse
Unigene: 211600 Human
Unigene: 116683 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TNFAIP3是一种泛素修饰酶,是机体重要的炎症反应负性调节因子,也是NF-κB的负调节蛋白。TNFAIP3蛋白与很多变态反应疾病的病理生理演变相关联,如:包括类风湿关节炎、冠状动脉疾病、银屑病、腹腔疾病、I型糖尿病、炎症性肠炎和系统性红斑狼疮等。
|
|