Rabbit Anti-TRPM2/FITC Conjugated antibody

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EREG 1; EREG1; TRPM2_HUMAN; Estrogen responsive element associated gene 1; Estrogen responsive element associated gene 1 protein; KNP 3; KNP3; Long transient receptor potential channel 2; LTRPC 2; LTRPC2; NUDT9H; NUDT9L1; putative Ca2+ channel protein; tr

Cat:

SL2888R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human TRPM2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

165kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
TRPM2 is a Ca(2+)-permeable channel that is activated by oxidative stress and confers susceptibility to cell death.

Subunit:
Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
Contains 1 nudix hydrolase domain.

Database links:

Entrez Gene: 7226 Human

Entrez Gene: 2848 Mouse

Entrez Gene: 294329 Rat

Omim: 603749 Human

SwissProt: O94759 Human

SwissProt: Q5KTC0 Mouse

SwissProt: Q91YD4 Mouse

SwissProt: Q5G856 Rat

Unigene: 369759 Human

Unigene: 276762 Mouse

Unigene: 214495 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

TRPM2 属于瞬时受体电位离子通道蛋白家族的M亚家族，是一种非选择性的阳离子通道蛋白, 是离子通道蛋白参与了单核细胞的氧化应激应答反应，与老年性痴呆等神经退行疾病的发生与发展有着十分密切的联系.

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