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Rabbit Anti-NAT2/FITC Conjugated antibody
background:
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq].
Function:
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the arylamine N-acetyltransferase family.
Database links:
Entrez Gene: 10 Human
Entrez Gene: 17961 Mouse
Omim: 612182 Human
SwissProt: P11245 Human
SwissProt: P50295 Mouse
Unigene: 2 Human
Unigene: 4695 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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