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Rabbit Anti-EDG6/FITC Conjugated antibody
background:
This protein belongs to a G protein coupled heptahelical receptor subfamily named Endothelial Cell Differentiation Genes (EDG)that act as receptors for biologically active lysophospholipids. This group consists of two receptor subgroups specific for S1P and LPA respectively. EDG6 is the receptor for lysophospholipid sphingosine 1 phosphate (S1P). S1P elicits diverse physiological effect on most types of cells and tissues. EDG6 may be involved in cell migration processes that are specific for lymphocytes.
Function:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 8698 Human
Entrez Gene: 13611 Mouse
Omim: 603751 Human
SwissProt: O95977 Human
SwissProt: Q9Z0L1 Mouse
Unigene: 662006 Human
Unigene: 33065 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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