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Rabbit Anti-MYL3/FITC Conjugated antibody
background:
Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains each ~200,000 daltons, and four light chains each ~16,000 - 21,000 daltons. Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. Human myosin light chain has clinical application as a cardiac marker.
Function:
Regulatory light chain of myosin. Does not bind calcium.
Subunit:
Myosin is a hexamer of 2 heavy chains and 4 light chains.
Post-translational modifications:
The N-terminus is blocked.
N-terminus is methylated by METTL11A/NTM1.
DISEASE:
Cardiomyopathy, familial hypertrophic 8 (CMH8)[MIM:608751]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Rarely, patients present a variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Contains 3 EF-hand domains.
Database links:
Entrez Gene: 4634 Human
Entrez Gene: 17897 Mouse
Entrez Gene: 24585 Rat
Omim: 160790 Human
SwissProt: P08590 Human
SwissProt: P09542 Mouse
SwissProt: P11289 Rat
Unigene: 517939 Human
Unigene: 7353 Mouse
Unigene: 1955 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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