Home
>
Product
>
Antibody
>
Rabbit Anti-Claudin 3/FITC Conjugated antibody
background:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subunit:
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
Subcellular Location:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
DISEASE:
Note=CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
Similarity:
Belongs to the claudin family.
Database links:
Entrez Gene: 1365 Human
Entrez Gene: 12739 Mouse
Entrez Gene: 65130 Rat
Omim: 602910 Human
SwissProt: O15551 Human
SwissProt: Q9Z0G9 Mouse
SwissProt: Q63400 Rat
Unigene: 647023 Human
Unigene: 158662 Mouse
Unigene: 4513 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
