background:
The Olfactomedin family comprises a diverse group of secreted glycoproteins, which includes OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin and mycocilin. These proteins are implicated in the development of the nervous system. Specifically, OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse at E8-10, and later in brain tissue and in the zone of polarizing activity in the limb. Overexpression of OLFM1 causes an excess of neural crest emigrations and prolonged neural crest production. OLFM2 participates in the regulation of the development of the anterior nervous system. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).
Function:
Noelins belong to the olfactomedin family, which is comprised of extracellular proteins with proposed roles in neural and neural crest development.
Subcellular Location:
Endoplasmic reticulum lumen.
Similarity:
Contains 1 olfactomedin-like domain.
Database links:
Entrez Gene: 395535 Chicken
Entrez Gene: 10439 Human
Entrez Gene: 56177 Mouse
Entrez Gene: 93667 Rat
Omim: 605366 Human
SwissProt: Q9IAK4 Chicken
SwissProt: Q99784 Human
SwissProt: O88998 Mouse
SwissProt: Q62609 Rat
Unigene: 522484 Human
Unigene: 43278 Mouse
Unigene: 11005 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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