Rabbit Anti-Phospho-Acetyl Coenzyme A carboxylase alpha (Ser78)/FITC Conjugated antibody

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Acetyl Coenzyme A Carboxylase alpha (phospho S78); p-Acetyl Coenzyme A Carboxylase alpha (phospho S78); ACAC; ACACA; ACACA; ACACA_HUMAN; ACC alpha; ACC; ACC-alpha; ACC1; ACC1; ACCA; acetyl CoA carboxylase 1; acetyl Coenzyme A; Acetyl Coenzyme A; Biotin ca

Cat:

SL3036R-FITC

Species Reactivity：

(predicted: Human,Pig,Horse,)

Immunogen：

KLH conjugated Synthesised phosphopeptide derived from human Acetyl Coenzyme A carboxylase alpha around the phosphorylation site of Ser78

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

266kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACSLCalpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Subunit:
Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.

Post-translational modifications:
Phosphorylation on Ser-1263 is required for interaction with BRCA1.

DISEASE:
Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:613933]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.

Similarity:
Contains 1 ATP-grasp domain.
Contains 1 biotin carboxylation domain.
Contains 1 biotinyl-binding domain.
Contains 1 carboxyltransferase domain.

Database links:

Entrez Gene: 31 Human

Entrez Gene: 32 Human

Omim: 200350 Human

SwissProt: O00763 Human

SwissProt: Q13085 Human

Unigene: 160556 Human

Unigene: 234898 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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