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Rabbit Anti-CPSF4/FITC Conjugated antibody
background:
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
Subunit:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with FIP1L1.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the CPSF4/YTH1 family.
Contains 5 C3H1-type zinc fingers.
Contains 1 CCHSLCtype zinc finger.
Database links:
Entrez Gene: 10898 Human
Entrez Gene: 54188 Mouse
Entrez Gene: 304277 Rat
Omim: 603052 Human
SwissProt: O95639 Human
SwissProt: Q8BQZ5 Mouse
SwissProt: Q5FVR7 Rat
Unigene: 489287 Human
Unigene: 196884 Mouse
Unigene: 104788 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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