background:
The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Function:
May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair.
Subcellular Location:
Membrane; Single-pass type I membrane protein (Probable).
Tissue Specificity:
Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.
Similarity:
Belongs to the immunoglobulin superfamily. TIM family. Contains 1 Ig-like SLVtype (immunoglobulin-like)
Database links:
Entrez Gene: 26762 Human
Entrez Gene: 171283 Mouse
Entrez Gene: 286934 Rat
Omim: 606518 Human
SwissProt: Q96D42 Human
SwissProt: Q5QNS5 Mouse
SwissProt: O54947 Rat
Unigene: 129711 Human
Unigene: 17771 Mouse
Unigene: 11154 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
