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Rabbit Anti-Sema6A/FITC Conjugated antibody
background:
SEMA6A belongs to a subfamily characterized by an extracellular semaphorin domain, a transmembrane domain, and a long cytoplasmic tail. Members of this class can repel sympathetic and dorsal root ganglion axons in vitro, consistent with a traditional role as guidance signals. However, the length of the cytoplasmic tail, which includes an EVL-binding site in SEMA6A and an Src-binding site in SEMA6B, suggests that these semaphorins may also function as receptors. SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection. SEMA6A directly links the Ena/VASP and the semaphorin protein families since the SEMA6A protein is capable of selective binding to the protein EVL (Ena/VASP-like protein.
Function:
Can act as repulsive axon guidance cues. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.
Subunit:
Active as a homodimer or oligomer. Interacts with EVL.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.
Database links:
Entrez Gene: 516019 Cow
Entrez Gene: 57556 Human
Entrez Gene: 20358 Mouse
Omim: 605885 Human
SwissProt: Q9H2E6 Human
SwissProt: O35464 Mouse
Unigene: 156967 Human
Unigene: 40909 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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