Home
>
Product
>
Antibody
>
Rabbit Anti-LILRB3/CD85a/FITC Conjugated antibody
background:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
May act as receptor for class I MHC antigens.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Detected in monocytes and B-cells.
Database links:
Entrez Gene: 11025 Human
Omim: 604820 Human
SwissProt: O75022 Human
Unigene: 631592 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|