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Rabbit Anti-Heme Oxygenase 1/FITC Conjugated antibody
background:
The hemeoxygenase-1 calls that the hemoglobin oxidizes to synthesize the enzyme again-1( hemeoxygenase-1, HO-1) is the catalyst enzyme that a kind of hemoglobin declines the solution, under the NADPH and the cell dye P-450 revivification enzymes and the member oxygen functions, the catalyst HO-1 hemoglobin declines the solution as the courage green vegetable, CO and irons, the former revivification has the very strong anti- to oxidize the ability after become the red vegetable of courage , the latter is a kind of important letter to make the member.
Function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
Subcellular Location:
Microsome. Endoplasmic reticulum.
Tissue Specificity:
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
DISEASE:
Defects in HMOX1 are the cause of heme oxygenase 1 deficiency (HMOX1D) [MIM:614034]. A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.
Similarity:
Belongs to the heme oxygenase family.
Database links:
Entrez Gene: 442987 Dog
Entrez Gene: 3162 Human
Entrez Gene: 15368 Mouse
Entrez Gene: 24451 Rat
Omim: 141250 Human
SwissProt: Q5E9F2 Cow
SwissProt: P09601 Human
SwissProt: P14901 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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