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Rabbit Anti-CD134/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008].
Function:
Receptor for TNFSF4/OX40L/GP34.
Subunit:
Interacts with TRAF2, TRAF3 and TRAF5.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Contains 4 TNFR-Cys repeats.
Database links:
Entrez Gene: 7293 Human
Omim: 600315 Human
SwissProt: P43489 Human
Unigene: 129780 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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