Rabbit Anti-CD112/FITC Conjugated antibody

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Nectin-2; Nectin2; Nectin 2; CD 112; CD112; CD112 antigen; Herpes virus entry mediator B; Herpes virus entry protein B; Herpesvirus entry mediator B; Herpesvirus entry protein B; Hve B; HveB; Poliovirus receptor like 2; Poliovirus receptor related 2 (herp

Cat:

SL2679R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human CD112

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

Flow-Cyt=1:50-200ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

56kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Nectin 2 is a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like SLVtype domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Can form trans-heterodimers with PVRL3/nectin-3.

Function:
Probable cell adhesion protein.

Subunit:
Can form trans-heterodimers with PVRL3/nectin-3. Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHSLV1) mutant Rid1, herpes simplex virus 1 (HHSLV2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.

Database links:

Entrez Gene: 5819 Human

Entrez Gene: 19294 Mouse

Entrez Gene: 308417 Rat

Omim: 600798 Human

SwissProt: Q92692 Human

SwissProt: P32507 Mouse

Unigene: 655455 Human

Unigene: 4341 Mouse

Unigene: 203297 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞粘附分子Nectin-2（CD112）是一种同源性非钙依赖型的CAM，属免疫球蛋白超家族，由nectin-1、nectin-2、nectin-3组成，广泛存在于肿瘤、正常细胞，神经细胞、内皮细胞等，CD112也是单纯疱疹病毒(HSSLV1和HSSLV2)的受体，具有同型或异型细胞粘附活性.在多发性硬化中呈现高表达。

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