background:
NFAM1 activates cytokine gene promoters such as the IL13 and TNF-alpha promoters. It contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells.
Function:
May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.
Subunit:
Interacts with ZAP70 and SYK. No direct interaction with the B-cell antigen receptor (BCR).
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Note=Partially recruited to lipid rafts upon BCR stimulation.
Tissue Specificity:
Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T cells, and lung. Expressed at low level in non-immune tissue.
Post-translational modifications:
N-glycosylated.
Similarity:
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
Contains 1 ITAM domain.
Database links:
Entrez Gene: 150372 Human
Omim: 608740 Human
SwissProt: Q8NET5 Human
Unigene: 436677 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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