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Rabbit Anti-PENK/FITC Conjugated antibody
background:
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
Function:
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
Subcellular Location:
Secreted.
Post-translational modifications:
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Similarity:
Belongs to the opioid neuropeptide precursor family.
Database links:
Entrez Gene: 5179 Human
Entrez Gene: 18619 Mouse
Entrez Gene: 29237 Rat
Omim: 131330 Human
SwissProt: P01210 Human
SwissProt: P4405 Mouse
SwissProt: P04094 Rat
Unigene: 339831 Human
Unigene: 475097 Mouse
Unigene: 10015 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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