background:
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq].
Function:
Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form (By similarity). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear.
Subunit:
Homodimer. May interact with CEBPB.
Subcellular Location:
Golgi apparatus membrane; Single-pass membrane protein. Nucleus. Note=According to PubMed:12050152, some fraction may be nuclear. Prostaglandin E synthase 2 truncated form: Cytoplasm. Note=Synthetized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form.
Tissue Specificity:
Widely expressed. Expressed in brain, heart, liver, colon and lung.
Similarity:
Belongs to the GST superfamily.
Contains 1 glutaredoxin domain.
Contains 1 GST SLCterminal domain.
Database links:
Entrez Gene: 493639 Cow
Entrez Gene: 80142 Human
Entrez Gene: 96979 Mouse
Entrez Gene: 311865 Rat
Entrez Gene: 100294563 Sheep
Omim: 608152 Human
SwissProt: Q66LN0 Cow
SwissProt: Q9H7Z7 Human
SwissProt: Q8BWM0 Mouse
Unigene: 495219 Human
Unigene: 28048 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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