background:
JNK1(MAPK8) is a member of the MAP kinase family. JNK1 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7.
JNK2 (p54a, SAPK1a), along with JNK1 and JNK3, is thought to play an important role in nuclear signal transduction through its environmental stress activation and subsequent phosphorylation of the nuclear transcription factor p53.
JNK3 is a neuron-specific form of c-Jun N-terminal kinases. Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis.
The JNK pathway is critically involved in diabetes and levels are abnormally elevated in obesity.
Database links:
Entrez Gene: 5599 Human
Entrez Gene: 26419 Mouse
Entrez Gene: 116554 Rat
Omim: 601158 Human JNK1
SwissProt: P45983 Human JNK1
Unigene: 138211 Human JNK1
Unigene: 21495 Mouse JNK1
Unigene: 4090 Rat JNK1
Entrez Gene: 5601 Human JNK2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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