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Rabbit Anti-IL21R/FITC Conjugated antibody
background:
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
Function:
This is a receptor for interleukin-21.
Subunit:
Heterodimer with the common gamma subunit. Associates with JAK1.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
Post-translational modifications:
SLCmannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the SLVshaped receptor into an A-frame.
Similarity:
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Contains 2 fibronectin type-III domains.
Database links:
Entrez Gene: 50615 Human
Entrez Gene: 60504 Mouse
Entrez Gene: 308977 Rat
Omim: 605383 Human
SwissProt: Q9HBE5 Human
SwissProt: Q9JHX3 Mouse
SwissProt: Q5EBB1 Rat
Unigene: 210546 Human
Unigene: 155643 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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