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Home > Product > Antibody > Rabbit Anti-IL21/FITC Conjugated antibody
IL 21; IL21; IL-21; Interleukin 21; Interleukin21; Za11; IL21_HUMAN; Interleukin-21; interleukin-21 isoform; OTTHUMP00000164088.
Cat:
SL2621R-FITC
Species Reactivity：
(predicted: Human,Mouse,Rat,Dog,Pig,Cow,)
Immunogen：
KLH conjugated synthetic peptide derived from human IL-21
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
18kDa
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Product PDFs
Datasheet:


background:
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Function:
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.

Similarity:
Belongs to the IL-15/IL-21 family.

Database links:

Entrez Gene: 378475 Cow

Entrez Gene: 59067 Human

Entrez Gene: 60505 Mouse

Omim: 605384 Human

SwissProt: Q76LU5 Cow

SwissProt: Q9HBE4 Human

SwissProt: Q9ES17 Mouse

Unigene: 567559 Human

Unigene: 157689 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

白介素21是多效免疫调节活性的细胞因子,与其受体结合后可以调节并促进B细胞、T细胞、NK细胞的增殖、分化并提高NK细胞杀伤活性。
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