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Rabbit Anti-IL10RB/FITC Conjugated antibody
background:
Interleukin 10 binds specifically and with high affinity to cell surface receptors. Interleukin 10 receptors are members of the class II subgroup of the cytokine receptor superfamily. Mouse and human cDNA clones encoding the ligand binding IL10 receptor have been isolated. The IL10 receptor complex contains two distinct type II cytokine receptor subunits, the ligand binding IL10RA and the IL10RB. The coexpression of both chains is essential for IL10 induced signal transduction. The beta chain serves as an accessory chain essential for the active IL10 receptor complex and necessary for the initiation of signal transdunction. Interleukin 10 receptors are expressed in all cell types that are known to respond to IL10.
Subcellular Location:
Membrane; Single-pass type I membrane
Similarity:
Belongs to the type II cytokine receptor family.
Contains 2 fibronectin type-III domains.
Database links:
Entrez Gene: 3588 Human
Entrez Gene: 16155 Mouse
Entrez Gene: 304091 Rat
Omim: 123889 Human
SwissProt: Q08334 Human
SwissProt: Q61190 Mouse
Unigene: 654593 Human
Unigene: 4154 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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