Rabbit Anti-IL5RA/FITC Conjugated antibody

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Interleukin-5 receptor alpha; CD125 antigen; CDw125; HSIL5R3; IL5R; IL-5R; Interleukin 5 Receptor alpha; Interleukin 5 receptor subunit alpha; interleukin 5 receptor type 3; MGC26560; IL5RA; IL-5R alpha; IL5RA_HUMAN.

Cat:

SL2601R-FITC

Species Reactivity：

Human,Mouse,(predicted: Rat,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human IL-5R alpha

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

46kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3(IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5(IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.

Function:
This is the receptor for interleukin-5. The alpha chain binds to IL5.

Subunit:
Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed on eosinophils and basophils.

Similarity:
Belongs to the type I cytokine receptor family. Type 5 subfamily.

Database links:

Entrez Gene: 3568 Human

Entrez Gene: 16192 Mouse

Omim: 147851 Human

SwissProt: Q01344 Human

SwissProt: P21183 Mouse

Unigene: 207105 Human

Unigene: 68876 Human

Unigene: 3448 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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